 This site features MODi (pronounced as ¡°mod eye¡±), a powerful modification search engine that uses mass spectrometry data to identify protein modifications. MODi facilitates cutting-edge proteomics research by extensively searching through hundreds of potential modifications efficiently. Among the existing search tools, MODi can take the most number of modifications as its search parameter.
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Looking to dig deeper? Jump right into MODmap!
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After the initial MODi search, a more in-depth analysis for potential novel modification can be performed using MODmap in tandem with MODi. MODmap makes use of MODi¡¯s unsuccessful identifications and explores for potentially important rare and unknown modifications from modified regions in MS/MS spectra.
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Special search engine for disulfide linkage analysis, DBond.
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Certain post-translational modifications involve more than one peptide and thus cannot be easily searched by conventional modification search algorithms. We provide specialized software, DBond that can analyze intact disulfide linkage between two peptides. Disulfide linkages not only contribute to the stability of a protein¡¯s structure, but it is known to regulate mediation of various signaling pathways in a cell. It is of particular interest to biopharmaceutical industry as disulfide bridge characterization is an important part of acceptance criteria for biological products.
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Sponsors
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| Functional Proteomics Center |
National Core Research Center |
